Det medisinske fakultet

Institutt for farmakologi

Produksjonsdato : 2001-01-23
Katalogtype: Fullformat.

1
PublKat: A05 (Kapittel i faglig bok, rapport m.v. (t.o.m. 1998))
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Aamo, Trond
Medforf: Brørs, Odd
Medforf: Lien, Ernst A.
         UiB, Institutt for farmakologi
Tittel:  Legemiddelanalyser og rusmiddelanalyser.
Tidskr:  Norsk legemiddelhåndbok 1998-99 for helsepersonell
År:      1998
Side(r): 1043-1050
Språk:   nor
PublID:  r98030320
StatKat: f
LokalK:  NKAT 6

2
PublKat: A03 (Artikkel i nordisk vitenskapelig tidsskrift (t.o.m. 1998))
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Anker, Gun Birgitta
Medforf: Lønning, Per Eystein
         UiB, Seksjon for onkologi
Medforf: Aakvaag, Asbjørn
         UiB, Institutt for klinisk biokjemi
Medforf: Lien, Ernst Asbjørn
         UiB, Institutt for farmakologi
Tittel:  Thyroid function in postmenopausal breast cancer patients treated
         with tamoxifen
Tidskr:  The Scandinavian Journal of Clinical and Laboratory
         Investigation
ISSN:    0036-5513
År:      1998
Volum:   58
Side(r): 103-107
Språk:   eng
PublID:  r98030457
StatKat: f
LokalK:  KAT 1

3
PublKat: A11 (Artikkel i internasjonalt vitenskapelig tidsskrift med referee)
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Clarke, R.
Medforf: Smith, A. D.
Medforf: Jobst, K. A.
Medforf: Refsum, H.
         UiB, Institutt for farmakologi
Medforf: Sutton, L.
Medforf: Ueland, P. M.
         UiB, Institutt for farmakologi
Tittel:  Folate, vitamin B12, and serum total homocysteine levels in confirmed
         Alzheimer disease
Tidskr:  Arch Neurol
År:      1998
Volum:   55
Hefte:   11
Side(r): 1449-1455
SamEng:  BACKGROUND: Recent studies suggest that vascular disease may
         contribute to the cause of Alzheimer disease (AD). Since elevated
         plasma total homocys (tHcy) level is a risk factor for vascular
         disease, it may also be relevant to AD. OBJECTIVE: To examine the
         association of AD with blood levels of tHcy, and its biological
         determinants folate and vitamin B12. DESIGN: Case-control study of
         164 patients, aged 55 years or older, with a clinical diagnosis of
         dementia of Alzheimer type (DAT), including 76 patients with
         histologically confirmed AD and 108 control subjects. SETTING:
         Referral population to a hospital clinic between July 1988 and April
         1996. MAIN OUTCOME MEASURES: Serum tHcy, folate, and vitamin B12
         levels in patients and controls at entry; the odds ratio of DAT or
         confirmed AD with elevated tHcy or low vitamin levels; and the rate
         of disease progression in relation to tHcy levels at entry. RESULTS:
         Serum tHcy levels were significantly higher and serum folate and
         vitamin B12 levels were lower in patients with DAT and patients with
         histologically confirmed AD than in controls . The odds ratio of
         confirmed AD associated with a tHcy level in the top third (> or = 14
         micromol/L) compared with the bottom third ( or = 11 micromol/L) of
         the control distribution was 4.5 (95% confidence interval, 2.2-9.2),
         after adjustment for age, sex, social class, cigarette smoking, and
         apolipoprotein E epsilon4. . cont.in MEDLINE
Språk:   eng
PublID:  r99000617
StatKat: f
LokalK:  KAT 1

4
PublKat: A11 (Artikkel i internasjonalt vitenskapelig tidsskrift med referee)
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Clarke, R.
Medforf: Woodhouse, P.
Medforf: Ulvik, Arve
         UiB, Institutt for farmakologi
Medforf: Frost, C.
Medforf: Sherliker, P.
Medforf: Refsum, Helga
         UiB, Institutt for farmakologi
Medforf: Ueland, Per Magne
         UiB, Institutt for farmakologi
Medforf: Khaw, K. T.
Tittel:  Variability and determinants of total homocysteine concentrations in p
         lasma in an elderly population
Tidskr:  Clinical Chemistry
ISSN:    0009-9147
År:      1998
Volum:   44
Side(r): 102-107
Emneord: Aged, Aging, Blood Pressure/physiology, Cholesterol/blood, Comparativ
         e Study, Female, Folic Acid/blood, Homocysteine/*blood/genetics, Huma
         n, Male, Regression Analysis, Reproducibility of Results, Seasons, Se
         x Factors, Support, Non-U.S. Gov't, Vitamin B 12/blood
SamEng:  The variability of plasma total homocysteine (tHcy) was examined in 9
         6 individuals over a 1-yr period. Blood tHcy concentrations varied fr
         om 7.1 micromol/L in the bottom quintile to 14.5 micromol/L in the to
         p quintile. The mean tHcy was 10.4 micromol/L, the between-person SD
         was 2.5 micromol/L, and the within-person SD was 0.93 micromol/L. The
         re was little seasonal variation, and the reliability coefficient was
          0.88. Mean tHcy concentrations were inversely related to mean plasma
          folate (r = -0.36) and vitamin B12 (r = -0.35) concentrations. Media
         n tHcy concentrations were approximately 1 micromol/L higher in men t
         han in women and in older (70 to 74 years) than in younger (65 to 69
         years) individuals and higher in those with the TT and CT genotypes f
         or the methylenetetrahydrofolate reductase polymorphism than in those
          with the CC genotype (10.7 and 10.6 vs 9.6 micromol/L). Epidemiologi
         cal studies based on single tHcy measurements may underestimate the m
         agnitude of any risk associations with disease by 10-15%.
Språk:   eng
PublID:  r99012604
LokalK:  KAT 1

5
PublKat: A11 (Artikkel i internasjonalt vitenskapelig tidsskrift med referee)
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Fiskerstrand, T.
Medforf: Riedel, Bettina
         UiB, Institutt for farmakologi
Medforf: Ueland, Per Magne
         UiB, Institutt for farmakologi
Medforf: Seetharam, B.
Medforf: Pezacka, E. H.
Medforf: Gulati, S.
Medforf: Bose, S.
Medforf: Banerjee, R.
Medforf: Berge, Rolf Kristian
Medforf: Refsum, Helga
         UiB, Institutt for farmakologi
Tittel:  Disruption of a regulatory system involving cobalamin distribution and
          function in a methionine-dependent human glioma cell line
Tidskr:  Journal of Biological Chemistry
ISSN:    0021-9258
År:      1998
Volum:   273
Side(r): 20180-20184
Emneord: Feedback/physiology, Glioma/*metabolism, Homocysteine/pharmacology, H
         uman, Methionine/*pharmacology, Microsomes/enzymology, Mitochondria/e
         nzymology Nitrous Oxide/pharmacology, Receptors, Cell Surface/metabol
         ism, Tumor Cells, Cultured, Vitamin B 12/*metabolism, 5-Methyltetrahy
         drofolate-Homocysteine S-Methyltransferase/analysis
SamEng:  Cobalamin metabolism and function were investigated at the levels fro
         m transcobalamin II (TCII) receptor to the cobalamin-dependent enzyme
         s, methio synthase and methylmalonyl-CoA mutase, in a methionine- dep
         endent (P60) and a methionine-independent (P60H) glioma cell line. Us
         ing P60H as reference, the P60 cells cultured in a methionine medium
         had slightly lower TCII receptor activity and normal total cobalamin
         content, a moderately reduced microsomal and mitochondrial cobalamin(
         III) reductase activity but only trace amounts of the methylcobalamin
          and adenosylcobalamin cofactors. When transferred to a homocysteine
         medium without methionine, P60H cells showed a slightly enhanced TCII
          receptor activity, but the other cobalamin-related functions were es
         sentially unchanged. In contrast, the methionine- dependent P60 cells
          responded to homocysteine medium with a nearly 6- fold enhancement o
         f TCII receptor expression and a doubling of both the hydroxycobalami
         n content and the microsomal reductase activity. The mitochondrial re
         ductase and the cobalamin-related processes further down the pathway
         did not change markedly. In both cell lines, TCII receptor activity w
         as further increased when growth in homocysteine medium was combined
         with N2O exposure. These data suggest that low methionine and/or high
          homocysteine exert a positive feedback control on TCII receptor acti
         vity. The concurrent increase in hydroxycobalamin content and in micr
         osomal reductase activity are either subjected to similar regulation
         or secondary to increased cobalamin transport. This regulatory networ
         k is most prominent in the methionine-dependent P60 cells harboring a
          disruption of the network in the proximity of cobalamin(III) reducta
         se.
Språk:   eng
PublID:  r99012605
StatKat: f
LokalK:  KAT 1

6
PublKat: A11 (Artikkel i internasjonalt vitenskapelig tidsskrift med referee)
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Geisler, Jürgen
Medforf: Geisler, Stephanie
Medforf: Lønning, Per Eystein
Medforf: Smaaland, R.
Medforf: Tveit, K. M.
Medforf: Refsum, Helga
         UiB, Institutt for farmakologi
Medforf: Ueland, Per Magne
         UiB, Institutt for farmakologi
Tittel:  Changes in folate status as determined by reduction in total plasma
         homocysteine levels during leucovorin modulation of 5-fluorouracil
         therapy in cancer patients
Tidskr:  Clinical Cancer Research
ISSN:    1078-0432
År:      1998
Volum:   4
Side(r): 2125-2128
Emneord: Antineoplastic Agents, Breast Neoplasms/*blood/*drug therapy,
         Colorectal Neoplasms/*blood/*drug therapy, Creatinine/blood,
         Erythrocytes/metabolism, Female, Fluorouracil/administration
SamEng:  We measured plasma total homocysteine (tHcy) in 14 patients (13
         patients with colorectal cancer and 1 patient with breast cancer)
         during their firs treatment with 5-fluorouracil (5-FU) plus
         leucovorin [LV (5-FULV)]. Eight of these patients were investigated
         asecond time after 3-10 cycles (median, 4 cycles) with 5-FULV. Each
         cycle consisted of two administrations of 5-FU (500 mg/m2) and LV
         (60mg/m2) given 24 h apart. The first administration of 5-FULV on day
         1 of the first cycle induced a rapid reduction of the tHcy level from
         12.5 micromol/liter (10.4-15.1 micromol/liter; geometric mean with
         95% confidence interval of the mean) to 9.1 micromol/liter (7.5-11.1
         micromol/liter) in 24 h. tHcy remainedstable at this level after
         thesecond administration of 5- FULV. In addition, the 5-FULV regimen
         caused a concurrent 4-fold increase in both serum and erythrocyte
         folate. The fifth cycle with 5- FULV had only marginal effects on
         thetHcy level. 5-FU without LV modulation had no effect on the plasma
         tHcy or folate status in eight breast cancer patients. Our d ata
         establish the reduction of tHcy as a responsive indicator of LV
         pharmacodynamics.
Språk:   eng
PublID:  r99012606
LokalK:  KAT 1

7
PublKat: A11 (Artikkel i internasjonalt vitenskapelig tidsskrift med referee)
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Guttormsen, Anne Berit
         UiB, Institutt for farmakologi
Medforf: Ueland, Per Magne
         UiB, Institutt for farmakologi
Medforf: Lønning, P. E.
Medforf: Mella, O.
Medforf: Refsum, Helga
         UiB, Institutt for farmakologi
Tittel:  Kinetics of plasma total homocysteine in patients receiving high-dose
         methotrexate therapy
Tidskr:  Clinical Chemistry
ISSN:    0009-9147
År:      1998
Volum:   44
Side(r): 1987-1989
Emneord: Antimetabolites, Antineoplastic/administration
Språk:   eng
PublID:  r99012607
LokalK:  KAT 1

8
PublKat: A11 (Artikkel i internasjonalt vitenskapelig tidsskrift med referee)
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Nedrebø, B.G.
Medforf: Ericsson, U.-B.
         Malmö universitetssjukhus
Medforf: Nygård, Ottar
         UiB, Seksjon for medisinsk statistikk
Medforf: Refsum, Helga
         UiB, Institutt for farmakologi
Medforf: Ueland, Per Magne
         UiB, Institutt for farmakologi
Medforf: Aakvaag, Asbjørn
         UiB, Institutt for klinisk biokjemi
Medforf: Aanderud, Sylvi
         UiB, Medisinsk avdeling B
Medforf: Lien, Ernst Asbjørn
         UiB, Institutt for farmakologi
Tittel:  Plasma total homocysteine levels in hyperthyroid and hypothyroid patie
         nts
Tidskr:  Metabolism
ISSN:    0026-0495
År:      1998
Volum:   47
Hefte:   1
Side(r): 89-93
SamEng:  We found a higher plasma concentration of total homocysteine (tHcy),
         an independent risk factor for cardiovascular disease, in patients wi
         th hypothyroidism (mean, 16.3 mol/L; 95% confidence interval [Cl],
         14.7 to 17.9 mol/L) than in healthy controls (mean, 10.5 mol/L: 9
         5% CI, 10.1 to 10.9 mu mol/L). The tHcy level of hyperthyroid pa tien
         ts did not differsignificantly from that of the controls. Serum creat
         inine was higher in hypothyroid patients and lower in hyperthyroid pa
         tients than in controls, whereas serum folate was higher in hyperthyr
         oid patients compared with the two other groups. In multivariate anal
         ysis, these differences did not explain the higher tHcy concentration
          in hypothyroidism. We confirmed the o bservation of elevated serum c
         holesterol in hypothyroidism, which together with the hyperhomocystei
         nemia may contribute to an accelerated atherogenesis in these patient
         s.
Språk:   eng
PublID:  r98024553
StatKat: f
LokalK:  KAT 1

9
PublKat: A11 (Artikkel i internasjonalt vitenskapelig tidsskrift med referee)
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Nygård, Ottar
Medforf: Refsum, Helga
         UiB, Institutt for farmakologi
Medforf: Ueland, Per Magne
         UiB, Institutt for farmakologi
Medforf: Vollset, Stein Erik
Tittel:  Major lifestyle determinants of plasma total homocysteine
         distribution: the Hordaland Homocysteine Study [see comments]
Tidskr:  American Journal of Clinical Nutrition
ISSN:    0002-9165
År:      1998
Volum:   67
Side(r): 263-270
Emneord: Adult, Aged, Aging/blood, *Coffee/adverse effects, Cohort Studies,
         Comparative Study, Diet, Female, Folic Acid/*administration
SamEng:  We report on the location and skewness of the distribution of plasma
         total homocysteine (tHcy) according to lifestyle indexes in 11,941
         apparently healthy participants of the Hordaland Homocysteine Study.
         Most subjects were in two age groups: 9165 subjects were aged 40-42 y
         and 2351 subjects were aged 65-67 y. The remaining 425 subjects were
         of intermediate ages. In multivariate analysis, sex, age, folate
         intake, smoking status, and coffee consumption were the strongest
         determinants of tHcy concentration. The combined effect of the three
         modifiable factors was larger than the effect from each factor alone.
         A lifestyle profile characterized by low folate intakes, smoking, and
         coffee consumption was associated with a high median tHcy
         concentration and a pronounced skewness toward high tHcy values. In
         subjects characterized by a contrasting lifestyle profile [high
         folate intakes, nonsmoking status, and low coffee consumption ( 1
         cup/d)], tHcy values were almost normally distributed and the median
         concentration was 3.0-4.8 micromol/L lower. Among all 40-42-y-old
         subjects, the 95% reference ranges based on geometric mean tHcy
         concentrations were 5.1-16.5 micromol/L for women and 6.2-18.7
         micromol/L for men. The corresponding ranges for subjects
         characterized by high folate intakes, nonsmoking status, and low or
         moderate coffee consumption ( 5 cups/d) were 4.812.8 micromol/L and
         6.2-14.7 micromol/L. These findings are relevant for establishing
         adequate reference ranges for tHcy and emphasize folate intake,
         smoking status, and coffee consumption as major acquired determinants
         of tHcy concentration in this general population.
Språk:   eng
PublID:  r99012608
StatKat: f
LokalK:  KAT 1

10
PublKat: C13 (Doktoravhandling)
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for samfunnsmedisinske fag, Seksjon for medisinsk statistikk
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Nygård, Ottar
         UiB, Seksjon for medisinsk statistikk
Tittel:  The Hordaland Homocysteine Studies. Determinants and prognostic value
         of plasma total homocysteine
Serie:   Dr.med.
ISBN:    82-7788-061-8
År:      1998-06-19
Side(r): 1 b.
Utgiver: Department of Public Health and Primary Health Care, and Depa
         rtment of Pharmacology, University of Bergen, Norway
Tilgang: Byttekontoret, Universitetsbiblioteket i Bergen
Emneord: cardiovascular diseases, homocysteine, blood
SamEng:  http://www.fou.uib.no/drgrad/1998/139002/
URL:     http://www.uib.no/info/dr_grad/98/juni/nygard/nygard.html
Språk:   eng
PublID:  r99011270
StatKat: a
LokalK:  NKAT 4a

11
PublKat: A11 (Artikkel i internasjonalt vitenskapelig tidsskrift med referee)
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Refsum, Helga
         UiB, Institutt for farmakologi
Medforf: Ueland, Per Magne
         UiB, Institutt for farmakologi
Medforf: Nygård, O.
Medforf: Vollset, S. E.
Tittel:  Homocysteine and cardiovascular disease
Tidskr:  Annual Review of Medicine
ISSN:    0066-4219
År:      1998
Volum:   49
Side(r): 31-62
Emneord: Atherosclerosis/etiology, Cardiovascular
         Diseases/*etiology/genetics/mortality/prevention, Cerebral
         Arteriosclerosis, Coronary Arteriosclerosis/etiology, Folic Acid
         Deficiency/comp lications, Homocysteine/blood/genetics/*physiology,
         Peripheral Vascular Diseases/etiology, Vitamin B 12/therapeutic use,
SamEng:  An elevated level of total homocysteine (tHcy) in blood, denoted
         hyperhomocysteinemia, is emerging as a prevalent and strong risk
         factor for atherosclerotic vascular disease in the coronary,
         cerebral, and peripheral vessels, and for arterial and venous
         thromboembolism. The basis for these conclusions is data from about
         80 clinical and epidemiological studies including more than 10,000
         patients. Elevated tHcy confers a graded risk with no threshold, is
         independent of but may enhance the effect of the conventional risk
         factors, and seems to be a particularly strong predictor of
         cardiovascular mortality. Hyperhomocysteinemia is attributed to
         commonly occurring genetic and acquired factors including
         deficiencies of folate and vitamin B12. Supplementation with
         B-vitamins, in particular with folic acid, is an efficient, safe, and
         inexpensive means to reduce an elevated tHcy level. Studies are now
         in progr ess to establish whether such therapy will reduce
         cardiovascular risk.
Språk:   eng
PublID:  r99012610
LokalK:  KAT 1

12
PublKat: A11 (Artikkel i internasjonalt vitenskapelig tidsskrift med referee)
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Refsum, Helga
         UiB, Institutt for farmakologi
Medforf: Guttormsen, Anne Berit
         UiB, Institutt for farmakologi
Medforf: Fiskerstrand, Torunn
Medforf: Ueland, Per Magne
         UiB, Institutt for farmakologi
Tittel:  Hyperhomocysteinemia in terms of steady-state kinetics
Tidskr:  European Journal of Pediatrics
ISSN:    0340-6199
År:      1998
Volum:   157(Suppl 2)
Side(r): S45-9
Emneord: Cells, Cultured, Half-Life, Homocysteine/*blood/urine, Homocystinuria
         /metabolism, Human, Kidney/metabolism, Kinetics, Liver/metabolism
SamEng:  The plasma level of homocysteine (Hcy) and its oxidized products, i.e
         ., plasma total Hcy (tHcy), is a function of the influx rate of Hcy t
         o plasma the plasma tHcy clearance. In vitro experiments show that pr
         oliferating cells usually export more Hcy than stationary cells and t
         hat the Hcy export increases in response to high methionine, low fola
         te or low cobalamin level, and to agents interfering with Hcy remethy
         lation. Comparison between various cell types suggests that hepatocyt
         es have a unique ability to increase the Hcy export in response to ex
         tracellular methionine, probably due to its capacity to form adenosyl
         methionine. Some but not all cell types have an ability to use extrac
         ellular Hcy as a methionine source. Clearance studies in healthy subj
         ects indicate that about 1.2 mmol Hcy is supplied from the cells to p
         lasma per 24 h, which is only about 5-10% of total Hcy formed. Compar
         ison of area under the curves after administration of Hcy and methion
         ine shows that about 10% of the methionine administered is released t
         o plasma as Hcy. Notably, only a few percent of Hcy from plasma is ex
         creted unchanged in the urine, and this shows that most tHcy in plasm
         a is metabolized. Folate or cobalamin deficient patients have normal
         plasma tHcy clearance, which suggests that their elevated tHcy level
         is due to increased Hcy export from tissues into the plasma compartme
         nt. In contrast, the hyperhomocysteinemia in renal failure is account
         ed for by a marked reduction in tHcy clearance, suggesting an importa
         nt role of kidney in elimination of Hcy from plasma.
Språk:   eng
PublID:  r99012609
LokalK:  KAT 1

13
PublKat: A11 (Artikkel i internasjonalt vitenskapelig tidsskrift med referee)
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Ren, Jicun
         UiB, Institutt for farmakologi
Medforf: Ulvik, Arve
         UiB, Institutt for farmakologi
Medforf: Refsum, Helga
         UiB, Institutt for farmakologi
Medforf: Ueland, Per Magne
         UiB, Institutt for farmakologi
Tittel:  Chemical mismatch cleavage combined with capillary electrophoresis: de
         tection of mutations exon 8 of the cystathionine beta-synthase gene
Tidskr:  Clinical Chemistry
ISSN:    0009-9147
År:      1998
Volum:   44
Side(r): 2108-2114
Emneord: Cystathionine beta-Synthase/*genetics, DNA/chemistry/*genetics, Elect
         rophoresis, Capillary, *Exons, Homozygote, Human, Hydroxylamine, Osmi
         um Tetroxide, *Point Mutation, Polymerase Chain Reaction, *Polymorphi
         sm, Single-Stranded Conformational, Sensitivity and Specificity, Supp
         ort, Non-U.S. Gov't
Språk:   eng
PublID:  r99012611
LokalK:  KAT 1

14
PublKat: A11 (Artikkel i internasjonalt vitenskapelig tidsskrift med referee)
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Robinson, K.
Medforf: Arheart, K.
Medforf: Refsum, Helga
         UiB, Institutt for farmakologi
Medforf: Brattstrom, L
Medforf: Boers, G.
Medforf: Ueland, Per Magne
         UiB, Institutt for farmakologi
Medforf: Rubba, P.
Medforf: Palma-Reis, R.
Medforf: Meleady, R.
Medforf: Daly, L.
Medforf: Witteman, J.
Medforf: Graham, I.
Tittel:  Low circulating folate and vitamin B6 concentrations: risk factors for
          stroke, peripheral vascular disease, and coronary artery disease. Eur
         opean C Group [see comments]
Tidskr:  Circulation
ISSN:    0009-7322
År:      1998
Volum:   97
Side(r): 437-443
Emneord: Analysis of Variance, Atherosclerosis/blood, Avitaminosis/blood, Cere
         brovascular Disorders/*blood/*epidemiology, Coronary Disease/*blood/*
         epidemiology, Folic Acid/*blood, Homocysteine/blood, Multicenter Stud
         ies, Peripheral Vascular Diseases/*blood/*epidemiology, Pyridoxine/*b
         lood Risk Factors, Vascular Diseases/blood, Vitamins/blood
SamEng:  BACKGROUND: A high plasma homocysteine concentration is a risk factor
          for atherosclerosis, and circulating concentrations of homocysteine
         are relat to levels of folate and vitamin B6. This study was performe
         d to explore the interrelationships between homocysteine, B vitamins,
          and vascular diseases and to evaluate the role of these vitamins as
         risk factors for atherosclerosis. METHODS: In a multicenter case-cont
         rol study in Europe, 750 patients with documented vascular disease an
         d 800 control subjects frequency-matched for age and sex were compare
         d. Plasma levels of total homocysteine (before and after methionine l
         oading) were determined, as were those of red cell folate, vitamin B1
         2, and vitamin B6. RESULTS: In a conditional logistic regression mode
         l, homocysteine concentrations greater than the 80th percentile for c
         ontrol subjects either fasting (12.1 micromol/L) or after a methionin
         e load (38.0 micromol/L) were associated with an elevated risk of vas
         cular disease independent of all traditional risk factors. In additio
         n, concentrations of red cell folate below the lowest 10th percentile
          (513 nmol/L) and concentrations of vitamin B6 below the lowest 20th
         percentile (23.3 nmol/L) for control subjects were also associated wi
         th increased risk. This risk was independent of conventional risk fac
         tors and for folate was explained in part by increased homocysteine l
         evels. In contrast, the relationship between vitamin B6 and atheroscl
         erosis was independent of homocysteine levels both before and after m
         ethionine loading. CONCLUSIONS: Lower levels of folate and vitamin B6
          confer an increased risk of atherosclerosis. Clinical trials are now
          required to evaluate the effect of treatment with these vitamins in
         the primary and secondary prevention of vascular diseases.
Språk:   eng
PublID:  r99012612
LokalK:  KAT 1

15
PublKat: A03 (Artikkel i nordisk vitenskapelig tidsskrift (t.o.m. 1998))
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Schneede, Jørn
         UiB, Institutt for farmakologi
Medforf: Lindstedt, Gøran
Medforf: Burman, Pia
Medforf: Lindgren, Anders
Medforf: Persson, Lennart
Medforf: Rasmussen, Karsten
Medforf: Swolin, Birgitta
Tittel:  Hur ska vi utreda vitamin B12-brist?
Tidskr:  Klinisk Kemi i Norden
ISSN:    1101-2013
År:      1998
Volum:   10
Hefte:   2
Side(r): 54-58
Emneord: B12-mangelutredning
Språk:   swe
PublID:  r99009250
StatKat: f
LokalK:  AKAT 8

16
PublKat: A03 (Artikkel i nordisk vitenskapelig tidsskrift (t.o.m. 1998))
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Schneede, Jørn
         UiB, Institutt for farmakologi
Medforf: Hestad, Knut
Medforf: Baekkedal, Ole
Medforf: Kausland, Anders
Tittel:  Sammenligning av kobalaminverdier hos deprimerte og demente
         psykogeriatriske pasienter
Tidskr:  Tidsskrift for Den norske lægeforening
Red:     Nylenna, Magne
ISSN:    0029-2001
År:      1998-08-10
Volum:   118
Hefte:   18
Side(r): 2826-2826
Emneord: B12-mangel, psykogeriatri
Språk:   nor
PublID:  r99009251
StatKat: f
LokalK:  NKAT 8

17
PublKat: A11 (Artikkel i internasjonalt vitenskapelig tidsskrift med referee)
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Tonstad, S.
Medforf: Refsum, Helga
         UiB, Institutt for farmakologi
Medforf: Ose, L.
Medforf: Ueland, Per Magne
         UiB, Institutt for farmakologi
Tittel:  The C677T mutation in the methylenetetrahydrofolate reductase gene pre
         disposes to hyperhomocysteinemia in children with familial hypercholes
         terolemia treated with cholestyramine
Tidskr:  Journal of Pediatrics
ISSN:    0022-3476
År:      1998
Volum:   132
Side(r): 365-368
Emneord: Amine Oxidoreductases/*genetics, Anticholesteremic Agents/therapeutic
          use, Child, Cholestyramine/therapeutic use, Female, Folic Acid/blood
         , Genotyp Heterozygote, Homocysteine/*blood, Homozygote, Human, Hyper
         cholesterolemia, Familial/*blood/drug therapy/genetics, Male Mutation
         , Support, Non-U.S. Gov't
SamEng:  In children with familial hypercholesterolemia, heterozygosity and ho
         mozygosity for the C677T mutation in the methylenetetrahydrofolate re
         ductase gene was associated with low serum folate and increased susce
         ptibility to elevation of plasma total homocysteine during cholestyra
         mine treatment. Because of the independent relationship between eleva
         ted plasma total homocysteine and cardiovascular disease, folate supp
         lementation may be prudent in these children.
Språk:   eng
PublID:  r99012613
LokalK:  KAT 1

18
PublKat: A11 (Artikkel i internasjonalt vitenskapelig tidsskrift med referee)
Instit:  Universitetet i Bergen, Det medisinske fakultet, Institutt for farmakologi
Forf:    Ulvik, Arve
         UiB, Institutt for farmakologi
Medforf: Ren, Jicun
         UiB, Institutt for farmakologi
Medforf: Refsum, Helga
         UiB, Institutt for farmakologi
Medforf: Ueland, Per Magne
         UiB, Institutt for farmakologi
Tittel:  Simultaneous determination of methylenetetrahydrofolate reductase C677
         T and factor V G1691A genotypes by mutagenically separated PCR and mul
         tiple-injection capillary electrophoresis
Tidskr:  Clinical Chemistry
ISSN:    0009-9147
År:      1998
Volum:   44
Side(r): 264-269
Emneord: Amine Oxidoreductases/*genetics, Automation, DNA Mutational Analysis/
         *methods, DNA Primers/chemistry, Electrophoresis, Capillary, Factor V
         /*genetics, Fluorescence, Genotype, Homocysteine/blood, Lasers, Polym
         erase Chain Reaction, Risk Factors, Support, Non-U.S. Gov't, Thrombos
         is/genetics
SamEng:  The C677T mutation of the methylenetetrahydrofolate reductase gene an
         d the G1691A (Leiden) mutation of the factor V gene are established r
         isk facto for thromboembolic disease. We here present an assay for th
         e simultaneous genotyping of these common genetic variants. The assay
          involves a strategy based on multiplex mutagenically separated PCR p
         erformed in a single tube containing six primers. Separation of the r
         esulting four PCR products (197, 207, 233, and 246 bp) was performed
         by capillary electrophoresis coupled with laser-induced fluorescence
         detection. The time for the automated electrophoresis was reduced to
         2.5 min per sample by performing the capillary electrophoresis analys
         is in a multiple-injection mode.
Språk:   eng
PublID:  r99012614
LokalK:  KAT 1


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